I Am Worried That My Childhood Friend Is Too Cute! summary: After 10 years, Amano finally returned to his childhood city and was overjoyed to reunite with his friend Yukio Sawatari on the first day of his transfer. But, to his surprise, Yukio suddenly transformed into a woman due to an uncommon illness called "Idiopathic isoform metamorphosis," which affects only 1 in 100,000 people. Despite the confusion, Amano finds himself attracted to his now-feminine childhood friend, leading to a hilariously forbidden love story full of transsexual humor.